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M94A2692.TXT
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1994-10-25
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Document 2692
DOCN M94A2692
TI Evaluation of 7 simple/rapid HIV antibody assays using seroconversion
panels.
DT 9412
AU Vercauteren G; Beelaert G; Belsey E; Constantine N; van der Groen G;
Tamashiro H; Institute of Tropical Medicine, Department Infection &
Immunity,; Antwerpen, Belgium.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):246 (abstract no. PB0415). Unique
Identifier : AIDSLINE ICA10/94369883
AB OBJECTIVE: To evaluate the performance of 7 simple/rapid (S/R) HIV
antibody assays with visual reading using seroconversion panels.
METHODS: Seven S/R HIV antibody assays (Immunocomb Bispot, HIV Chek 1 +
2, Recombigen HIV-1/HIV-2 rapid test device, Serodia HIV-1, Serodia
HIV-1/2, Capillus HIV1/HIV2, Test pack) were assessed using 11
seroconversion panels (BBI and Serologicals). Results were compared to
the Abbott Recombinant HIV-1/HIV-2 3rd generation EIA (reference test)
which consistently detected antibody at an early time post infection.
RESULTS: All of the S/R assays detected antibody on the same day as the
reference test in at least 5 of the 11 panels. Overall, the S/R assays
detected antibody on the average between 0.5 and 4.2 days later than the
reference test. On two occasions some of the simple tests were even
earlier positive than the reference test. One test performed
significantly worse (p < 0.01) than the reference test. The additional
risks compared to the reference test of missing an infectious unit of
blood during seroconversion by using the worst of the simple tests
ranges from 1 per 100 million to 1 in 100,000 at an incidence of 0.0001%
and 0.1% respectively. CONCLUSIONS: We conclude that, although there are
differences in sensitivity between the S/R assays with visual reading
when used to test blood from individuals during the course of
seroconversion, the differences are small and comparable with those
obtained by the more sophisticated ELISA tests.
DE AIDS Serodiagnosis/*METHODS Blood Banks Comparative Study Human HIV
Seropositivity/*DIAGNOSIS/IMMUNOLOGY HIV-1/*IMMUNOLOGY
HIV-2/*IMMUNOLOGY *Immunoenzyme Techniques Predictive Value of Tests
Reference Values MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).